α-MSH (11-13) (free acid)
- Product Name
- α-MSH (11-13) (free acid)
- CAS No.
- 67727-97-3
- Chemical Name
- α-MSH (11-13) (free acid)
- Synonyms
- KPV;msh(11-13;ACTH-(11-13);H-Lys-Pro-Val-OH;ALPHA-MSH (11-13);α-MSH(11-13)[pig];α-MSH(11-13)[human];H-LYS-PRO-VAL-OH ACOH;α-Melanotropin(11-13);alpha-MSH(11-13) acetate
- CBNumber
- CB1241534
- Molecular Formula
- C16H30N4O4
- Formula Weight
- 342.43
- MOL File
- 67727-97-3.mol
α-MSH (11-13) (free acid) Property
- storage temp.
- -15°C
- InChI
- InChI=1S/C16H30N4O4/c1-10(2)13(16(23)24)19-14(21)12-7-5-9-20(12)15(22)11(18)6-3-4-8-17/h10-13H,3-9,17-18H2,1-2H3,(H,19,21)(H,23,24)/t11-,12-,13-/m0/s1
- InChIKey
- YSPZCHGIWAQVKQ-AVGNSLFASA-N
- SMILES
- C(O)(=O)[C@H](C(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)N
N-Bromosuccinimide Price
- Product number
- PRO0001392
- Product name
- ALPHA-MSH (11-13) ACETATE SALT
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.86
- Updated
- 2021/12/16
- Product number
- MT-19210
- Product name
- alpha-Msh(11-13)(freeacid)acetatesalt
- Purity
- 98%
- Packaging
- 0.25g
- Price
- $898
- Updated
- 2021/12/16
α-MSH (11-13) (free acid) Chemical Properties,Usage,Production
Definition
ChEBI: Lys-Pro-Val is an oligopeptide.
Biological Activity
The C-terminal tripeptide α-MSH(11–13), also known as KPV (L-Lys-L-Pro-L-Val), exhibited anti-inflammation without induction of cutaneous pigmentation in a frog skin bioassay. The underlying molecular mechanisms of the α-MSH(11–13) anti-inflammatory properties have not been determined in detail. However, they are related to an inhibition of TNF-α, IL-6, and nitric oxide production in a model of LPS-stimulated murine microglial cell culture[1]. Furthermore, it has been recently shown that α-MSH(11–13) reduces activation of NF-κB and decreases its translocation into the nucleus by interaction with importin family proteins.
References
[1] Eva-Verena Schaible. “Single administration of tripeptide α-MSH(11-13) attenuates brain damage by reduced inflammation and apoptosis after experimental traumatic brain injury in mice.” PLoS ONE (2013): e71056.
α-MSH (11-13) (free acid) Preparation Products And Raw materials
Raw materials
Preparation Products
α-MSH (11-13) (free acid) Suppliers
- Tel
- +16314854226
- inquiry@bocsci.com
- Country
- United States
- ProdList
- 19743
- Advantage
- 58
- Tel
- +1-781-999-5354
- support@targetmol.com
- Country
- United States
- ProdList
- 19973
- Advantage
- 58
View Lastest Price from α-MSH (11-13) (free acid) manufacturers
- Product
- KPV 67727-97-3
- Price
- US $50.00/box
- Min. Order
- 1box
- Purity
- >99%
- Supply Ability
- 20tons
- Release date
- 2023-10-12
- Product
- KPV 67727-97-3
- Price
- US $80.00-75.00/Box
- Min. Order
- 1Box
- Purity
- 99%
- Supply Ability
- 66666
- Release date
- 2023-12-18
- Product
- KPV 67727-97-3
- Price
- US $10.00-100.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100 tons
- Release date
- 2024-01-12